Home

Who we are

Why we exist

In the news

The Experts speak
> Henry McCandless
>
> Arthur Schafer

Upcoming events

How to help

The Experts Speak

Citizen Audit of Responsibilities, Performance and Accountabilities in the Apotex Inc. Influence Issue at The University of Toronto's Hospital for Sick Children, 1996-1999.
- A Report by the Alliance for Public Accountability, February 2000.

  SUMMARY
Main Message
Summary Audit Observations
Summary Recommendation
General Observations
Specific Recommendations
   


I.
II.









III.








IV.



V.



VI.



VII.



VIII.



IX.







X.







XI.



XII.



XIII.

THE REPORT
Introduction to Citizen Audit
Introduction to the APA report
     Purpose of the Report
     Who Had What Responsibilities and Accountabilities?
     Basic Principles and Concepts Used in the Report
            The precautionary principle
            The principle of directing-mind responsibility
            The principle of self-informing
            The principle of management control
            The concepts of responsibility and accountability
            The concept of public accountability
What Happened at the Hospital
     Government policy affecting research
     The deferiprone (L1) research
     Warning signs
     Apotex's action
     The disclosure issue
     Hospital officials' and Board's response
     The Naimark consulting assignment
     January 1999 events
Board of Trustees responsibilities, Performance and Answering
     Board of Trustees Responsibilities
     Board of Trustees Performance
     Board of Trustees Answering
Hospital Executive Responsibilities, Performance and Answering
     Executive Responsibilities
     Executive Performance
     Executive Answering
Senior Medical research Officials Responsibilities, Performance and Answering
     Research Officials Responsibilities
     Research Officials Performance
     Research Officials Answering
Researchers Responsibilities, Performance and Answering
     Researchers Responsibilities
     Researchers Performance
     Researchers Answering
University of Toronto Responsibilities, Performance and Answering
     University Responsibilities
     University Performance
     University Answering
Health Protection Branch Responsibilities, Performance and Answering
     Health Protection Branch Responsibilities
            HPB responsibilities related to the Toronto Deferiprone trial
            Minister's responsibilities in funding and safety policy
     Health Protection Branch Performance
            HPB performance in safety-based policy for drugs
            HPB performance in the deferiprone trial
     Health Protection Branch Answering
Medical Research Council Responsibilities, Performance and Answering
     Medical Research Council (MRC) Responsibilities
            MRC responsibilities in research funding policy
            MRC responsibilities in the deferiprone trial
     Medical Research Council Performance
            MRC performance in research funding policy
            MRC performance related to the Toronto clinical trial
     Medical Research Council Answering
Apotex's Responsibilities, Performance and Answering
     Apotex's Responsibilities
     Apotex's Performance
     Apotex's Answering
Epilogue: Events Subsequent to 25 January 1999
     Hospital and University Officials' Actions
     The Harassment Mail Issue
     Statements Made in January-February 2000
Conclusion
   
  APPENDICES
Appendix 1 Principles of Effective Governance
Appendix 2 Observations on the Naimark Consulting Assignment
Appendix 3 The University President's 25 January 1999 Agreement
Appendix 4 Deferiprone in Europe in 1999

 

 
Copyright 2001 Doctors for Research Integrity.